Guidelines for the diagnosis, treatment, prevention and control of infections caused by carbapenem-resistant gram-negative bacilli

作者：Mei Zeng, Jun Xia, Zhiyong Zong, Yi Shi, Yuxing Ni, Fupin Hu, Yijian Chen, Chao Zhuo, Bijie Hu, Xiaoju Lv, Jia-Bin Li, Zhengyin Liu, Jing Zhang, Wenjie Yang, Fan Yang, Qiwen Yang, Hua Zhou, Xin Li, Jianhua Wang, Yimin Li, Jianan Ren, Baiyi Chen, Dechang Chen, Anhua Wu, Xiangdong Guan, Jieming Qu, Depei Wu, Xiao‐Jun Huang, Haibo Qiu, Yingchun Xu, Yunsong Yu, Minggui Wang · 发表于：Journal of Microbiology Immunology and Infection · 年份：2023 · DOI：10.1016/j.jmii.2023.01.017 · 被引用次数：137 · 研究领域：Antibiotic Resistance in Bacteria、Antibiotic Use and Resistance、Bacterial Identification and Susceptibility Testing

The dissemination of carbapenem-resistant Gram-negative bacilli (CRGNB) is a global public health issue. CRGNB isolates are usually extensively drug-resistant or pandrug-resistant, resulting in limited antimicrobial treatment options and high mortality. A multidisciplinary guideline development group covering clinical infectious diseases, clinical microbiology, clinical pharmacology, infection control, and guideline methodology experts jointly developed the present clinical practice guidelines based on best available scientific evidence to address the clinical issues regarding laboratory testing, antimicrobial therapy, and prevention of CRGNB infections. This guideline focuses on carbapenem-resistant Enterobacteriales (CRE), carbapenem-resistant Acinetobacter baumannii (CRAB), and carbapenem-resistant Pseudomonas aeruginosa (CRPA). Sixteen clinical questions were proposed from the perspective of current clinical practice and translated into research questions using PICO (population, intervention, comparator, and outcomes) format to collect and synthesize relevant evidence to inform corresponding recommendations. The grading of recommendations, assessment, development and evaluation (GRADE) approach was used to evaluate the quality of evidence, benefit and risk profile of corresponding interventions and formulate recommendations or suggestions. Evidence extracted from systematic reviews and randomized controlled trials (RCTs) was considered preferentially for treatment-related...