Global, regional, and national burden of multiple sclerosis from 1990 to 2019: Findings of global burden of disease study 2019

作者：Zhen Qian, Yuancun Li, Zhiqiang Guan, P Guo, Ke Zheng, Yali Du, Shengjie Yin, Binyao Chen, Hongxi Wang, Jiao Jiang, Kunliang Qiu, Mingzhi Zhang · 发表于：Frontiers in Public Health · 年份：2023 · DOI：10.3389/fpubh.2023.1073278 · 被引用次数：76 · 研究领域：Multiple Sclerosis Research Studies、Vaccine Coverage and Hesitancy、Systemic Sclerosis and Related Diseases

Background: The global rising prevalence and incidence of multiple sclerosis (MS) has been reported during the past decades. However, details regarding the evolution of MS burden have not been fully studied. This study aimed to investigate the global, regional, and national burden and temporal trends in MS incidence, deaths, and disability-adjusted life years (DALYs) from 1990 to 2019 using the age-period-cohort analysis. Methods: We performed a secondary comprehensive analysis of incidence, deaths, and DALYs of MS by calculating the estimated annual percentage change from 1990 to 2019 obtained from the Global Burden of Disease (GBD) 2019 study. The independent age, period, and birth cohort effects were evaluated by an age-period-cohort model. Results: In 2019, there were 59,345 incident MS cases and 22,439 MS deaths worldwide. The global number of incidences, deaths, and DALYs of MS followed an upward trend, whereas the age-standardized rates (ASR) slightly declined from 1990 to 2019. High socio-demographic index (SDI) regions had the highest ASR of incidences, deaths, and DALYs in 2019, while the rate of deaths and DALYs in medium SDI regions are the lowest. Six regions which include high-income North America, Western Europe, Australasia, Central Europe, and Eastern Europe had higher ASR of incidences, deaths, and DALYs than other regions in 2019. The age effect showed that the relative risks (RRs) of incidence and DALYs reached the peak at ages 30-39 and 50-59, respectivel...