Long-term effect of hospital volume on the postoperative prognosis of 158,618 patients with esophageal squamous cell carcinoma in China

作者：Ling-Ling Lei, Xin Song, Xueke Zhao, Rui‐Hua Xu, Mengxia Wei, Lin Sun, Panpan Wang, Miaomiao Yang, Jingfeng Hu, Kan Zhong, Wen-Li Han, Xue-Na Han, Zong-Min Fan, Ran Wang, Bei Li, Fuyou Zhou, Xianzeng Wang, Liguo Zhang, Qi-De Bao, Yanru Qin, Zhiwei Chang, Jian-Wei Ku, Haijun Yang, Ling Yuan, Jingli Ren, Xuemin Li, Lidong Wang · 发表于：Frontiers in Oncology · 年份：2023 · DOI：10.3389/fonc.2022.1056086 · 被引用次数：10 · 研究领域：Esophageal Cancer Research and Treatment、Pancreatic and Hepatic Oncology Research、Head and Neck Cancer Studies

Background: The impact of hospital volume on the long-term survival of esophageal squamous cell carcinoma (ESCC) has not been well assessed in China, especially for stage I-III stage ESCC. We performed a large sample size study to assess the relationships between hospital volume and the effectiveness of ESCC treatment and the hospital volume value at the lowest risk of all-cause mortality after esophagectomy in China. Aim: To investigate the prognostic value of hospital volume for assessing postoperative long-term survival of ESCC patients in China. Methods: test and analysis of variance. The Kaplan-Meier method with the log-rank test was used to draw the survival curves for the variables tested. A Multivariate Cox proportional hazards regression model was used to analyze the independent prognostic factors for overall survival. The relationship between hospital volume and all-cause mortality was assessed using restricted cubic splines from Cox proportional hazards models. The primary outcome was all-cause mortality. Results: In both 1973-1996 and 1997-2020, patients with stage I-III stage ESCC who underwent surgery in high volume hospitals had better survival than those who underwent surgery in low volume hospitals (both P<0.05). And high volume hospital was an independent factor for better prognosis in ESCC patients. The relationship between hospital volume and the risk of all-cause mortality was half-U-shaped, but overall, hospital volume was a protective factor for esophag...