Organocatalytic asymmetric synthesis of P-stereogenic molecules

作者：Junyang Liu, Hang Chen, Min Wang, Wangjin He, Jia‐Lei Yan · 发表于：Frontiers in Chemistry · 年份：2023 · DOI：10.3389/fchem.2023.1132025 · 被引用次数：24 · 研究领域：Organophosphorus compounds synthesis、Asymmetric Synthesis and Catalysis、Synthetic Organic Chemistry Methods

P-chirality broadly appears in natural and synthetic functional molecules. The catalytic synthesis of organophosphorus compounds bearing P-stereogenic centers is still challenging, due to the lack of efficient catalytic systems. This review summarizes the key achievements in organocatalytic methodologies for the synthesis of P-stereogenic molecules. Different catalytic systems are emphasized for each strategy class (desymmetrization, kinetic resolution, and dynamic kinetic resolution) with examples cited to illustrate the potential applications of the accessed P-stereogenic organophosphorus compounds.