Clinical characteristics and long-term management of prepubertal testicular teratomas: a retrospective, multicenter study

作者：Guanglun Zhou, Fenglan Sun, Xin Yu, Ruifeng Huang, Xiaodong Liu, Yaoling Ouyang, Zhilin Yang, Shoulin Li · 发表于：European Journal of Pediatrics · 年份：2023 · DOI：10.1007/s00431-023-04859-8 · 被引用次数：13 · 研究领域：Testicular diseases and treatments、Sexual Differentiation and Disorders、Sarcoma Diagnosis and Treatment

Prepubertal testicular teratomas are rare tumors with limited practical guidance for their management. This study aimed to analyze a large multicenter database to establish the optimal management of testicular teratomas. We retrospectively collected data on testicular teratomas in children younger than 12 years who underwent surgery without postoperative chemotherapy in three large professional children's institutions in China between 2007 and 2021. The biological behavior and long-term outcomes of testicular teratomas were analyzed. In total, 487 children (with 393 mature teratomas and 94 immature teratomas) were included. Among mature teratomas, 375 cases were testis-sparing, 18 were orchiectomies, 346 were operated through the scrotal approach, and 47 underwent the inguinal approach. The median follow-up period was 70 months, and no recurrence or testicular atrophy was observed. Among the children with immature teratomas, 54 underwent testis-sparing surgery, 40 underwent orchiectomy, 43 were operated through the scrotal approach, and 51 were operated through the inguinal approach. Two cases of immature teratomas with cryptorchidism had local recurrence or metastasis within 1 year of the operation. The median follow-up duration was 76 months. No other patients had recurrence, metastasis, or testicular atrophy. Conclusion: Testicular-sparing surgery is the first treatment choice for prepubertal testicular teratomas, with the scrotal approach being a safe and well-tolerated s...