A gut-brain axis mediates sodium appetite via gastrointestinal peptide regulation on a medulla-hypothalamic circuit

作者：Yuchu Liu, Ji‐an Wei, Zhihua Luo, Jing Cui, Yifan Luo, S. Mak, Siqi Wang, Fengwei Zhang, Yan Yang, Kwok‐Fai So, Lingling Shi, Li Zhang, Bkc Chow · 发表于：Science Advances · 年份：2023 · DOI：10.1126/sciadv.add5330 · 被引用次数：19 · 研究领域：Regulation of Appetite and Obesity、Neuroendocrine regulation and behavior、Biochemical Analysis and Sensing Techniques

Salt homeostasis is orchestrated by both neural circuits and peripheral endocrine factors. The colon is one of the primary sites for electrolyte absorption, while its potential role in modulating sodium intake remains unclear. Here, we revealed that a gastrointestinal hormone, secretin, is released from colon endocrine cells under body sodium deficiency and is indispensable for inducing salt appetite. As the neural substrate, circulating secretin activates specific receptors in the nucleus of the solitary tracts, which further activates the downstream paraventricular nucleus of the hypothalamus, resulting in enhanced sodium intake. These results demonstrated a previously unrecognized gut-brain pathway for the timely regulation of sodium homeostasis.