Increases prognostic value of clinical-pathological nomogram in patients with esophageal squamous cell carcinoma

作者：Jing Feng Hu, Xin Song, Kan Zhong, Xue Zhao, Fu You Zhou, Rui‐Hua Xu, Ji Lin Li, Xian Zeng Wang, Xue Min Li, Pan Pan Wang, Ling Lei, Meng Xia Wei, Ran Wang, Zong Min Fan, Xue Han, Yao Chen, Liu Yu Li, Jia Jia Ji, Yuan Yang, Bei Li, Miao Miao Yang, Hai Jun Yang, Fu Bao Chang, Jing Ren, Sheng Zhou, Lidong Wang · 发表于：Frontiers in Oncology · 年份：2023 · DOI：10.3389/fonc.2023.997776 · 被引用次数：10 · 研究领域：Esophageal Cancer Research and Treatment、Head and Neck Cancer Studies、Cancer Research and Treatment

Background This study was intended to construct a brand new prognostic nomogram after combine clinical and pathological characteristics to increases prognostic value in patients with esophageal squamous cell carcinoma. Methods A total of 1,634 patients were included. Subsequently, the tumor tissues of all patients were prepared into tissue microarrays. AIPATHWELL software was employed to explore tissue microarrays and calculate the tumor-stroma ratio. X-tile was adopted to find the optimal cut-off value. Univariate and multivariate Cox analyses were used to screen out remarkable characteristics for constructing the nomogram in the total populations. A novel prognostic nomogram with clinical and pathological characteristics was constructed on the basis of the training cohort (n=1,144). What’s more performance was validated in the validation cohort (n=490). Clinical-pathological nomogram were assessed by concordance index, time-dependent receiver operating characteristic, calibration curve and decision curve analysis. Results The patients can divide into two groups with cut-off value of 69.78 for the tumor-stroma ratio. It is noteworthy that the survival difference was noticeable ( P <0.001). A clinical-pathological nomogram was constructed by combining clinical and pathological characteristics to predict the overall survival. In comparison with TNM stage, the concordance index and time-dependent receiver operating characteristic of the clinical-pathological nomogram sho...