Mycobacterium bovis BCG Given at Birth Followed by Inactivated Respiratory Syncytial Virus Vaccine Prevents Vaccine-Enhanced Disease by Promoting Trained Macrophages and Resident Memory T Cells

作者：Yang Wang, Fei Ge, Junhai Wang, Hanglin Li, Boyang Zheng, Wenjian Li, Shunyan Chen, Xiaoqing Zheng, Yuqing Deng, Yueling Wang, Ruihong Zeng · 发表于：Journal of Virology · 年份：2023 · DOI：10.1128/jvi.01764-22 · 被引用次数：11 · 研究领域：Immune responses and vaccinations、Neonatal Respiratory Health Research、Respiratory viral infections research

RSV is the leading cause of severe lower respiratory tract infection of infants. ERD, characterized by Th2-biased responses, inflammation, and poor immune memory, has been an obstacle to the development of safe and effective killed RSV vaccines.