Multi-layer-structured bioactive glass nanopowder for multistage-stimulated hemostasis and wound repair

作者：Yidan Wang, Meng Luo, Ting Li, Chenxi Xie, Sihua Li, Bo Lei · 发表于：Bioactive Materials · 年份：2023 · DOI：10.1016/j.bioactmat.2023.01.019 · 被引用次数：93 · 研究领域：Wound Healing and Treatments、Hemostasis and retained surgical items、Surgical Sutures and Adhesives

Current treatments for full-thickness skin injuries are still unsatisfactory due to the lack of hierarchically stimulated dressings that can integrate the rapid hemostasis, inflammation regulation, and skin tissue remodeling into the one system instead of single-stage boosting. In this work, a multilayer-structured bioactive glass nanopowder ([email protected]) is developed by coating the poly-tannic acid and ε-polylysine onto the BGN via facile layer-by-layer assembly as an integrative and multilevel dressing for the sequential management of wounds. In comparison to BGN and poly-tannic acid coated BGN, [email protected] exhibited the better hemostatic performance because of its multiple dependent approaches to induce the platelet adhesion/activation, red blood cells (RBCs) aggregation and fibrin network formation. Simultaneously, the bioactive ions from BGN facilitate the regulation of the inflammatory response while the poly-tannic acid and antibacterial ε-polylysine prevent the wound infection, promoting the wound healing during the inflammatory stage. In addition, [email protected] can serve as a reactive oxygen species scavenger, alleviate the oxidation stress in wound injury, induce the cell migration and angiogenesis, and promote the proliferation stage of wound repair. Therefore, [email protected] demonstrated the significantly higher wound repair capacity than the commercial bioglass dressing Dermlin™. This multifunctional [email protected] is a potentially valuable ...