Association between diverticular disease and colorectal cancer: a bidirectional mendelian randomization study

作者：Y. Zhang, Han Zhang, Jinghan Zhu, Yazhou He, Peng Wang, Doudou Li, Xiaozhuan Liu, Wen Jin, Junxi Zhang, Chuan Xu, Zengli Yu, Xin Zhao, Lingling Cui · 发表于：BMC Cancer · 年份：2023 · DOI：10.1186/s12885-023-10606-x · 被引用次数：10 · 研究领域：Diverticular Disease and Complications、Congenital gastrointestinal and neural anomalies、Urinary and Genital Oncology Studies

BACKGROUND: Diverticular disease has been inconsistently associated with colorectal cancer risk. We conducted a bidirectional Mendelian randomization study to assess this association. METHODS: ) were selected as instrumental variables from large-scale genome-wide association studies of European descent, respectively. Summary-level data for colon cancer, rectum cancer, and colorectal cancer were obtained from genome-wide association analyses of the FinnGen consortium and the UK Biobank study. Summary-level data for diverticular disease was derived from a genome-wide association study conducted in the UK Biobank population. The random effect inverse-variance weighted Mendelian randomization approach was used as the primary method and MR-Egger, weighted-median, and MR-PRESSO approaches were conducted as sensitivity analyses. RESULTS: Genetically determined diverticular disease was associated with a higher risk of colorectal cancer (beta = 0.441, 95%CI: 0.081-0.801, P = 0.016) in the FinnGen population, but the association was not found in the UK Biobank (beta = 0.208, 95%CI: -0.291,0.532, P = 0.207). The positive association remained consistent direction in the three sensitivity analyses. In the stratified analysis in the FinnGen consortium, an association was found to exist between genetically predicted diverticular disease and colon cancer (beta = 0.489, 95%CI: 0.020-0.959, P = 0.041), rather than rectum cancer (beta = 0.328, 95%CI: -0.119-0.775, P = 0.151). Besides, we found ...