Development of Diagnostic Recommendations for Vitreoretinal Lymphoma

作者：Xiao Zhang, Yan Zhang, Wenxue Guan, Dongmei Zou, Chan Zhao, Fei Gao, Rongping Dai, Weihong Yu, Youxin Chen, Hanyi Min, Meifen Zhang, Wei Zhang, Xiaoyan Peng · 发表于：Ocular Immunology and Inflammation · 年份：2023 · DOI：10.1080/09273948.2023.2173242 · 被引用次数：12 · 研究领域：CNS Lymphoma Diagnosis and Treatment、Lymphoma Diagnosis and Treatment、Chronic Lymphocytic Leukemia Research

PURPOSE: To develop diagnostic recommendations for diffuse large B-cell vitreoretinal lymphoma (VRL) in Chinese patients. METHODS: Retrospective observational case series. Seventy-three eyes of 40 VRL patients and 8 control patients were analyzed. Eighteen patients from Beijing Tongren Hospital and 46 patients from literature were involved as validations. RESULTS: Diagnostic methods included (1) typical clinical manifestations; (2) vitreous cytology; (3) immunohistochemical examination of vitreous or choroid/retina; (4) aqueous humor or vitreous cytokine; (5) vitreous cell gene rearrangement; (6) vitreous flow cytometry. If patients meet (1)+(2)+(3), or if they meet (1), and two of (4), (5), (6) are positive, they can be diagnosed as VRL. The sensitivity and specificity values for accurate diagnosis were 0.975 and 1.00. One hundred percent eyes from Beijing Tongren Hospital and 92.7% eyes from literature can be diagnosed. CONCLUSION: We developed diagnostic recommendations for diffuse large B-cell VRL through vitreous cytology combined with multiple auxiliary examinations.