Nickel-Catalyzed Desulfonylative Reductive Cross-Coupling of Aryl Sulfones with Aryl Bromides

作者：Xinmiao Huang, Ling Tang, Zhiyong Song, Shuangshuang Jiang, Xianmao Liu, Ming Ma, Bo Chen, Yuanhong Ma · 发表于：Organic Letters · 年份：2023 · DOI：10.1021/acs.orglett.3c00185 · 被引用次数：31 · 研究领域：Sulfur-Based Synthesis Techniques、Catalytic C–H Functionalization Methods、Catalytic Cross-Coupling Reactions

Herein, a nickel catalysis system for desulfonylative C(sp 2 )–C(sp 2 ) reductive cross-coupling reactions of aryl sulfone derivatives with a range of aryl bromides has been established to form diverse biaryl compounds. The complex Ar–Ni(II)–SO 2 CF 3 bearing a phosphine ligand through oxidative addition of aryl sulfone to Ni(0) species was isolated and confirmed by an X-ray, which provides solid evidence for the understanding of the C(Ar)–SO 2 bond activation and reaction mechanism.