Correlation of the BRAFV600E and RAS mutations with clinicopathological characteristics of papillary thyroid cancer using TCGA database analysis

作者：Yue Zhao, Bing‐Jie Wu, Duo-Duo Wang · 发表于：DOAJ (DOAJ: Directory of Open Access Journals) · 年份：2019 · 研究领域：Radiomics and Machine Learning in Medical Imaging

Objective: To investigate the occurrence of BRAFV600E and RAS mutations in thyroid papillary
\ncarcinoma (PTC) and to study their correlation with clinicopathological features of PTC.
\nMethods Relevant information of PTC was downloaded and organized from The Cancer
\nGenome Atlas (TCGA) via cBioPortal, then the gene mutation and clinical information of
\n402 PTC samples were analyzed. The correlation of BRAFV600E and RAS mutations with
\nclinicopathological features and prognosis of PTC were subjected to univariate analysis.
\nSecondly, we use Binary Logistic multivariate analysis to analyze the factors screened above.
\nResults BRAFV600E mutation rate is 48.5% (195/402) and RAS mutation rate is 10.2% (41/402)
\nin 402 cases of PTC. Univariate analysis showed that BRAFV600E mutation has nothing to do
\nwith age and sex of the patient. There is a significant correlation among BRAFV600E mutation
\nand lymph node metastasis, extrathyroidal invasion, staging, recurrence, progression and
\npathological subtypes in PTC. There is no significant correlation among RAS and age, sex,
\nstaging, recurrence, progression. There is a significant correlation among RAS and lymph node
\nmetastasis, extrathyroidal invasion and pathological subtypes in PTC. Multivariate logistic
\nregression analysis indicated that there is a significant correlation among BRAFV600E mutation
\nand extrathyroidal invasion, pathological subtypes in PTC. T...