Stratum corneum hydration inversely correlates with certain serum cytokine levels in the elderly, possibly contributing to inflammaging

作者：Bin Yang, Chengzhi Lv, Li Ye, Zhen Wang, Yoon Kim, Wenhai Luo, Peter M. Elias, Mao‐Qiang Man · 发表于：Immunity & Ageing · 年份：2023 · DOI：10.1186/s12979-023-00331-1 · 被引用次数：24 · 研究领域：Advancements in Transdermal Drug Delivery、Dermatology and Skin Diseases、Allergic Rhinitis and Sensitization

BACKGROUND: Chronic, low-grade inflammation, also termed 'inflammaging', has been linked to the development of some aging-associated disorders. Recent studies suggest that inflammaging is attributable to aging-associated epidermal dysfunction. However, abnormality in which epidermal function contributes to inflammaging is not clear. OBJECTIVE: We delineated the correlation of epidermal functions with circulating levels of proinflammatory cytokines in the elderly. METHODS: Blood sample was collected from a total of 255 participants aged ≥ 65 years. Epidermal biophysical properties were measured on the left forearm and the right shin. Serum cytokine levels were measured by Multiplex Luminex Assays. RESULTS: Neither skin surface pH nor transepidermal water loss rates (TEWL) correlated with serum cytokine levels except TEWL on the right shin for TNFa (p < 0.05). In contrast, stratum corneum hydration levels on both the forearm and the shin correlated negatively with serum cytokine levels (p < 0.05). CONCLUSION: Reduced stratum corneum hydration likely contributes to inflammaging.