Clinical characteristics and predictive model of pulmonary tuberculosis patients with pulmonary fungal coinfection

作者：Hongxuan Yan, Li Guo, Yu Pang, Fangchao Liu, Tianhui Liu, Mengqiu Gao · 发表于：BMC Pulmonary Medicine · 年份：2023 · DOI：10.1186/s12890-023-02344-4 · 被引用次数：12 · 研究领域：Antifungal resistance and susceptibility、Tuberculosis Research and Epidemiology、Pneumocystis jirovecii pneumonia detection and treatment

BACKGROUND: In clinical settings, pulmonary tuberculosis (PTB) patients were often found to have pulmonary fungal coinfection. This study aimed to assess the clinical characteristics of patients suffering from coinfection with TB and pulmonary fungal and construct a predictive model for evaluating the probability of pulmonary fungal coinfection in patients with pulmonary tuberculosis. METHODS: The present case-control study retrospectively collected information from 286 patients affected by PTB who received treatment from December 6,2016- December 6,2021 at Beijing Chest Hospital, Capital Medical University. As control subjects, patients with sex and address corresponding to those of the case subjects were included in the study in a ratio of 1:1. These 286 patients were randomly divided into the training and internal validation sets in a ratio of 3:1. Chi-square test and logistic regression analysis were performed for the training set, and a predictive model was developed using the selected predictors. Bootstrapping was performed for internal validation. RESULTS: Seven variables [illness course, pulmonary cavitation, broad-spectrum antibiotics use for at least 1 week, chemotherapy or immunosuppressants, surgery, bacterial pneumonia, and hypoproteinemia] were validated and used to develop a predictive model which showed good discrimination capability for both training set [area under the curve (AUC) = 0.860, 95% confidence interval (CI) = 0.811-0.909] and internal validation s...