Asthma with recurrent middle lobe syndrome in children: Clinical features and lung function patterns

作者：Yong Feng, Haoting Yu, Xin Liu, Ning Chen, Yunxiao Shang, Han Zhang · 发表于：Frontiers in Pediatrics · 年份：2023 · DOI：10.3389/fped.2023.1113652 · 被引用次数：2 · 研究领域：Asthma and respiratory diseases、Tracheal and airway disorders、Oral and Craniofacial Lesions

Background Middle lobe syndrome (MLS) is a complication of childhood asthma. This study aimed to compare the clinical features and lung function between asthmatic children with recurrent MLS and transient right middle lobe (RML) and/or lingula atelectasis. Methods This study retrospectively analyzed asthmatic children with RML and/or lingula atelectasis between 2010 and 2020 using data from the pediatric pulmonary department. According to the episodes of atelectasis, children were divided into recurrent (≥2 episodes) and non-recurrent (only 1 episode) MLS groups, to compare clinical features and lung function. Spirometry during acute asthma exacerbation and stable stages were recorded, and variations were calculated. Results A total of 35 children with asthma and RML and/or lingula atelectasis were included, 15 of whom had recurrent MLS. The recurrent MLS group had a higher proportion of girls, infections, family allergy history, severe asthma, severe exacerbation, and higher levels of total IgE than the non-recurrent MLS group ( P < 0.05). The recurrent MLS group had a significantly higher % predicted and z-scores for forced expiratory volume in 1 s (FEV 1 ) and forced vital capacity (FVC), a greater proportion of high FEV 1 and higher variations in FEV 1 and FVC than that in the non-recurrent group ( P < 0.05). After excluding children with mild to moderate asthma in the recurrent MLS group, the differences in clinical features disappeared, but the results reg...