Efficacy of Fufang E’jiao Jiang in the Treatment of Patients with Qi and Blood Deficiency Syndrome: A Real‐World Prospective Multicenter Study with a Patient Registry

作者：Mengjie Zhao, Mengli Xiao, Jiake Ying, Panbo Qiu, Hongxian Wu, Qin Tan, Shiliang Chen, Lulu Zhang, Sanfei Shi, Guida Li, Yang Zhao, Fang Lü · 发表于：Evidence-based Complementary and Alternative Medicine · 年份：2023 · DOI：10.1155/2023/3179489 · 被引用次数：8 · 研究领域：Traditional Chinese Medicine Studies、Traditional Chinese Medicine Analysis、Gastrointestinal motility and disorders

Objective . This nationwide, multicenter prospective observational study with a patient registry was designed to evaluate the efficacy of Fufang E’jiao Jiang (FEJ) in Chinese patients with Qi and blood deficiency syndrome (QBDS). Methods . QBDS patients were consecutively recruited from 81 investigational sites in China from July, 2019, to December, 2020. Patients who met the eligibility criteria were enrolled in a prospective registry database. Baseline characteristics and changes in scores on the traditional Chinese medicine (TCM) symptom evaluation scale for Qi and blood deficiency, the clinical global impression (CGI) scale, the fatigue scale‐14 (FS‐14), and the Pittsburgh sleep quality index (PSQI) were analyzed to determine the clinical efficacy of FEJ. Results . A total of 3,203 patients were recruited. The average remission rate (i.e., the sum of the cure rate and improvement rate) of the 20 symptoms of QBDS was 92.49% after 4 weeks of FEJ treatment, which was higher than at baseline; the rate increased to 94.69% at 8 weeks. The CGI scale revealed that the number of total remissions at 4 and 8 weeks was 3,120 (97.41%) and 415 (100%), respectively. The total FS‐14 scores decreased by 1.67 ± 4.11 ( p < 0.001) at 4 weeks and 1.72 ± 3.09 ( p < 0.001) at 8 weeks of treatment. The PSQI scores were 6.6 ± 4.7 and 6.52 ± 3.07 at 4 and 8 weeks, respectively, which were significantly lower than the baseline scores ( p < 0.001; p = 0.0033). Both the subhealth fatigue (SF...