Maternal age at childbirth and the risk of attention-deficit/hyperactivity disorder and learning disability in offspring

作者：Ling Gao, Songtao Li, Yulin Yue, Guangfeng Long · 发表于：Frontiers in Public Health · 年份：2023 · DOI：10.3389/fpubh.2023.923133 · 被引用次数：31 · 研究领域：Attention Deficit Hyperactivity Disorder、Prenatal Substance Exposure Effects、Maternal Mental Health During Pregnancy and Postpartum

Background Studies have shown that young maternal age at childbirth can increase the risk of attention-deficit/hyperactivity disorder (ADHD) in offspring, but a study of the U.S. population has not been reported. Moreover, there is no reported research on young and advanced maternal age at childbirth and whether it can contribute to the risk of learning disability (LD) in offspring. Methods This study evaluated the association between young and advanced maternal age at childbirth and offspring risk of ADHD and LD in the U.S. population. Using data from 8,098 participants included in the National Health and Nutrition Examination Survey (NHANES) conducted in 1999–2004, we analyzed the association between maternal age at childbirth and ADHD and LD risk in offspring. Odds ratios (ORs) and 95% confidence intervals (CIs) for maternal age at childbirth in association with ADHD and LD risk in offspring were estimated using multivariate logistic regression models after adjustment for age, sex, race, body mass index (BMI), poverty income ratio, smoking status during pregnancy, and NHANES cycle. Restricted cubic spline (RCS) models were used to evaluate potential non-linear relationships. Sensitivity analyses were performed to ensure the reliability of the results. Results Among all participants, the offspring of subjects with a maternal age at childbirth of 18–24 years had an increased risk of ADHD (OR = 1.34, 95% CI: 1.01, 1.79) and LD (OR = 1.36, 95% CI: 1.06, 1.79) or either ADHD or...