Efficacy of Hydroxychloroquine in Pre-Exposure Severe Acute Respiratory Syndrome Coronavirus 2 Prophylaxis Among High-Risk Healthcare Workers: A Multicenter Study

作者：Elahe Nasri, Hamed Fakhim, Mehrdad Salahi, Safiyeh Ghafel, Samane Pourajam, Ali Darakhshandeh, Nazila Kassaian, Somayeh Sadeghi, Behrooz Ataei, Shaghayegh Haghjooy Javanmard, Afsane Vaezi · 发表于：Advanced Biomedical Research · 年份：2023 · DOI：10.4103/abr.abr_104_21 · 被引用次数：1 · 研究领域：COVID-19 Clinical Research Studies、Diverse Scientific Research Studies、Antibiotic Use and Resistance

Background: Prophylaxis could be an established strategy to potentially prevent and control infectious diseases and should be considered in the coronavirus disease 2019 (COVID-19) pandemic. The present study aimed to assess the effectiveness of hydroxychloroquine as a prophylaxis treatment strategy in the reduction of the risk of COVID-19 among health professionals. Materials and Methods: The health professionals were randomly assigned (1:1) to the control group without receiving any hydroxychloroquine as prophylaxis and the hydroxychloroquine group receiving a weekly hydroxychloroquine dose of 400 mg up to 12 weeks. Results: A total of 146 health professionals were randomly enrolled in this study between August 11 and November 11 in 2020. Among the screened health professionals, 21 (14.6%) were infected with COVID-19 during the 12 weeks, and 14 (66.6%) out of the 21 health professionals were in the control group. Most participants with COVID-19 had mild symptoms (62%). In addition, 9.5% ( n = 2) of the participants suffered from moderate disease and 28.5% were diagnosed with severe symptoms. In the hydroxychloroquine group, 5 (7.1%) and 2 (2.8%) participants were reported with mild and moderate symptoms of COVID-19, respectively, and 2 participants had moderate, 8 (10.9%) participants had mild symptoms, and 6 (8.2%) participants had severe symptoms in the control group, within 3 months. Severe symptoms of COVID-19 were not observed in the hydroxychloroquine group. Conclusion...