Remodeling of the brain correlates with gait instability in cervical spondylotic myelopathy

作者：Xianyong Wu, Ying Wang, Jianchao Chang, Kun Zhu, Siya Zhang, Yan Li, Junxun Zuo, Senlin Chen, Weiming Jin, Tingfei Yan, Kun Yang, Peng Xu, Peiwen Song, Yuanyuan Wu, Yinfeng Qian, Cailiang Shen, Yongqiang Yu, Fulong Dong · 发表于：Frontiers in Neuroscience · 年份：2023 · DOI：10.3389/fnins.2023.1087945 · 被引用次数：7 · 研究领域：Cervical and Thoracic Myelopathy、Advanced Neuroimaging Techniques and Applications、Functional Brain Connectivity Studies

Introduction: Cervical spondylotic myelopathy (CSM) is a common form of non-traumatic spinal cord injury (SCI) and usually leads to remodeling of the brain and spinal cord. In CSM with gait instability, the remodeling of the brain and cervical spinal cord is unclear. We attempted to explore the remodeling of these patients' brains and spinal cords, as well as the relationship between the remodeling of the brain and spinal cord and gait instability. Methods: According to the CSM patients' gait, we divided patients into two groups: normal gait patients (nPT) and abnormal gait patients (aPT). Voxel-wise z-score transformation amplitude of low-frequency fluctuations (zALFF) and resting-state functional connectivity (rs-FC) were performed for estimating brain changes. Cross-sectional area (CSA) and fractional anisotropy (FA) of the spinal cord were computed by Spinal cord toolbox. Correlations of these measures and the modified Japanese Orthopedic Association (mJOA) score were analyzed. Results: We found that the zALFF of caudate nucleus in aPT was higher than that in healthy controls (HC) and lower than that in nPT. The zALFF of the right postcentral gyrus and paracentral lobule in HC was higher than those of aPT and nPT. Compared with the nPT, the aPT showed increased functional connectivity between the caudate nucleus and left angular gyrus, bilateral precuneus and bilateral posterior cingulate cortex (PCC), which constitute a vital section of the default mode network (DMN). No...