Siderophore-Based Noninvasive Differentiation of Aspergillus fumigatus Colonization and Invasion in Pulmonary Aspergillosis

作者：Dominika Luptáková, Rutuja H. Patil, Radim Dobiáš, David A. Stevens, Tomáš Pluháček, Andrea Palyzová, Marcela Káňová, Milan Navrátil, Zbyněk Vrba, Petr Hubáček, Vladimı́r Havlı́ček · 发表于：Microbiology Spectrum · 年份：2023 · DOI：10.1128/spectrum.04068-22 · 被引用次数：20 · 研究领域：Antifungal resistance and susceptibility、Plant Pathogens and Fungal Diseases、Fungal Biology and Applications

The importance of this research lies in the demonstration that siderophore analysis can distinguish between asymptomatic colonization and invasive pulmonary aspergillosis. We found clear associations between phases of fungal development, from conidial germination to the proliferative stage of invasive aspergillosis, and changes in secondary metabolite secretion.