Serum per- and polyfluoroalkyl substances and abnormal lipid metabolism: A nationally representative cross-sectional study

作者：Bing Wu, Yitao Pan, Zheng Li, Jinghua Wang, Saisai Ji, Feng Zhao, Xiaochen Chang, Yingli Qu, Yuanduo Zhu, Linna Xie, Yawei Li, Zheng Zhang, Haocan Song, Xiaojian Hu, Yidan Qiu, Xulin Zheng, Wenli Zhang, Yanwei Yang, Heng Gu, Fangyu Li, Jiayi Cai, Ying Zhu, Zhaojin Cao, John S. Ji, Yuebin Lv, Jiayin Dai, Xiaoming Shi · 发表于：Environment International · 年份：2023 · DOI：10.1016/j.envint.2023.107779 · 被引用次数：85 · 研究领域：Per- and polyfluoroalkyl substances research、Fluorine in Organic Chemistry、Hemoglobin structure and function

BACKGROUND: The associations of legacy per- and polyfluoroalkyl substances (PFAS) with lipid metabolism are controversial, and there is little information about the impact of emerging PFAS (6:2 Cl-PFESA) on lipid metabolism in China. OBJECTIVES: We aimed to explore the associations of legacy and emerging PFAS with lipid profiles and dyslipidemia in Chinese adults. METHODS: We included 10,855 Chinese participants aged 18 years and above in the China National Human Biomonitoring. The associations of 8 PFAS with 5 lipid profiles and 4 dyslipidemia were investigated using weighted multiple linear regression or weighted logistic regression, and the dose-response associations were investigated using restricted cubic spline model. RESULTS: Among the 8 PFAS, the concentration of PFOS was the highest, with a geometric mean of 5.15 ng/mL, followed by PFOA and 6:2 Cl-PFESA, which were 4.26 and 1.63 ng/mL, respectively. Legacy (PFOA, PFOS, PFUnDA) or emerging (6:2 Cl-PFESA) PFAS were associated with lipid profiles (TC, LDL-C, HDL-C, non HDL-C) and dyslipidemia (high LDL-C, high TC, low HDL-C), and their effects on TC were most obvious. TC concentration increased by 0.595 mmol/L in the highest quartile (Q4) of PFOS when compared with the lowest quartile (Q1), (95 % CI:0.396, 0.794). Restricted cubic spline models showed that PFAS are nonlinearly associated with TC, non HDL-C, LDL-C and HDL-C, and that the lipid concentrations tend to be stable when PFOS and PFOA were > 20 ng/mL well as wh...