T cells and their products in diabetic kidney disease

作者：Yue Liu, Yaodong Lv, Tingwei Zhang, Tongtong Huang, Yating Lang, Qinghao Sheng, Yingxiao Liu, Zhijuan Kong, Ying Gao, Shangwei Lu, Meilin Yang, Yaqi Luan, Xining Wang, Zhimei Lv · 发表于：Frontiers in Immunology · 年份：2023 · DOI：10.3389/fimmu.2023.1084448 · 被引用次数：65 · 研究领域：Diabetes and associated disorders、T-cell and B-cell Immunology、Immune Cell Function and Interaction

Diabetic kidney disease (DKD) is the most common cause of end-stage renal disease and has gradually become a public health problem worldwide. DKD is increasingly recognized as a comprehensive inflammatory disease that is largely regulated by T cells. Given the pivotal role of T cells and T cells-producing cytokines in DKD, we summarized recent advances concerning T cells in the progression of type 2 diabetic nephropathy and provided a novel perspective of immune-related factors in diabetes. Specific emphasis is placed on the classification of T cells, process of T cell recruitment, function of T cells in the development of diabetic kidney damage, and potential treatments and therapeutic strategies involving T cells.