Metastable Iron Sulfides: A Versatile Antibacterial Candidate with Multiple Mechanisms against Bacterial Resistance

作者：Haolin Cao, Qian Wang, Xiaonan Wang, Lei Chen, Jing Jiang, Lizeng Gao · 发表于：Accounts of Materials Research · 年份：2023 · DOI：10.1021/accountsmr.2c00177 · 被引用次数：24 · 研究领域：Garlic and Onion Studies、Pharmaceutical and Antibiotic Environmental Impacts、Essential Oils and Antimicrobial Activity

Conspectus Bacterial infections pose an ongoing threat to global human health, an issue of growing urgency due to the emergence of resistance against many currently available antibiotics. Recently, the World Health Organization (WHO) launched a global appeal for the development of novel antibiotics to combat this issue. Ideal antibiotics should possess specific antibacterial effects, without causing resistance. However, the discovery of different antibiotics is lagging the development of drug-resistant bacteria. Many newly developed antibiotics not only are rapidly resisted by bacteria but also are ineffective against persistent bacteria embedded in biofilms and host cells. To tackle these challenges, innovative concepts and approaches are required for the discovery of novel antibacterial candidates. Agents for use against pathogenic bacteria were developed long before the discovery of antibiotics. For 3000 years, garlic has been considered an efficient antibacterial compound, utilized to prevent and treat bacterial infection worldwide, although the specific mechanisms remain unclear. Modern research shows that sulfur-containing chemicals are the primary active constituents of garlic and play key roles in its inherent antimicrobial activity, such as diallyl disulfide (DADS) and diallyl trisulfide (DATS). In contrast, inorganic sulfides for antibacterial use have not been deeply studied. It has been well-known that iron sulfides are an essential part of the geochemical and bio...