Transcranial ultrasound stimulation modulates the interhemispheric balance of excitability in human motor cortex

作者：Liyuan Ren, Zhaolin Zhai, Qiong Xiang, Kaiming Zhuo, Suzhen Zhang, Yi Zhang, Xiong Jiao, Shanbao Tong, Dengtang Liu, Junfeng Sun · 发表于：Journal of Neural Engineering · 年份：2023 · DOI：10.1088/1741-2552/acb50d · 被引用次数：26 · 研究领域：Transcranial Magnetic Stimulation Studies、Photoacoustic and Ultrasonic Imaging、Optical Imaging and Spectroscopy Techniques

Abstract Background . Low-intensity transcranial ultrasound stimulation (TUS) could induce both immediate and long-lasting neuromodulatory effects in human brains. Interhemispheric imbalance at prefrontal or motor cortices generally associates with various cognitive decline in aging and mental disorders. However, whether TUS could modulate the interhemispheric balance of excitability in human brain remains unknown. Objective . This study aims to explore whether repetitive TUS (rTUS) intervention can modulate the interhemispheric balance of excitability between bilateral motor cortex (M1) in healthy subjects. Approach . Motor evoked potentials (MEPs) at bilateral M1 were measured at 15 min and 0 min before a 15 min active or sham rTUS intervention on left M1 and at 0 min, 15 min and 30 min after the intervention, and the Chinese version of brief neurocognitive test battery (C-BCT) was conducted before and after the intervention respectively. Cortical excitability was quantified by MEPs, and the long-lasting changes of MEP amplitude was used as an index of plasticity. Results . In the active rTUS group ( n = 20), the ipsilateral MEP amplitude increased significantly compared with baselines and lasted for up to 30 min after intervention, while the contralateral MEP amplitude decreased lasting for 15 min, yielding increased laterality between bilateral MEPs. Furthermore, rTUS intervention induced changes in some C-BCT scores, and the changes of scores correlated with the changes ...