Persistent COVID-19 Symptoms at 6 Months After Onset and the Role of Vaccination Before or After SARS-CoV-2 Infection

作者：Stephanie A Richard, Simon D. Pollett, Anthony C Fries, Catherine M Berjohn, Ryan C. Maves, Tahaniyat Lalani, Alfred Glaze Smith, Rupal M. Mody, Anuradha Ganesan, Rhonda E Colombo, David A Lindholm, Michael J. Morris, Nikhil Huprikar, Christopher J. Colombo, Cristian Madar, Milissa U. Jones, Derek Thomas Larson, Samantha E. Bazan, Katrin Mende, David Saunders, Jeffrey Livezey, Charlotte Anne Lanteri, I Scher, Celia Byrne, Jennifer A. Rusiecki, Evan C. Ewers, Nusrat J Epsi, Julia S Rozman, Caroline L. English, Mark P. Simons, David R. Tribble, Brian K. Agan, Timothy H. Burgess, Terry Merritt, Susan V. Chambers, Cristin Mount, Michael Ashley Stein, CATHERINE F. T. UYEHARA, Heidi L. Adams, Patrick W. Hickey, Edward Parmelee, Mark Fritschlanski, T Chao, Richard R. Chapleau, Monica Christian, Kelsey R Lanter, Jennifer R Meyer, John K. Iskander, Kathryn Lago · 发表于：JAMA Network Open · 年份：2023 · DOI：10.1001/jamanetworkopen.2022.51360 · 被引用次数：91 · 研究领域：Long-Term Effects of COVID-19、SARS-CoV-2 and COVID-19 Research、Pharmacological Receptor Mechanisms and Effects

Importance: Understanding the factors associated with post-COVID conditions is important for prevention. Objective: To identify characteristics associated with persistent post-COVID-19 symptoms and to describe post-COVID-19 medical encounters. Design, Setting, and Participants: This cohort study used data from the Epidemiology, Immunology, and Clinical Characteristics of Emerging Infectious Diseases With Pandemic Potential (EPICC) study implemented in the US military health system (MHS); MHS beneficiaries aged 18 years or older who tested positive for SARS-CoV-2 from February 28, 2020, through December 31, 2021, were analyzed, with 1-year follow-up. Exposures: SARS-CoV-2 infection. Main Outcomes and Measures: The outcomes analyzed included survey-reported symptoms through 6 months after SARS-CoV-2 infection and International Statistical Classification of Diseases and Related Health Problems, Tenth Revision diagnosis categories reported in medical records 6 months following SARS-CoV-2 infection vs 3 months before infection. Results: More than half of the 1832 participants in these analyses were aged 18 to 44 years (1226 [66.9%]; mean [SD] age, 40.5 [13.7] years), were male (1118 [61.0%]), were unvaccinated at the time of their infection (1413 [77.1%]), and had no comorbidities (1290 [70.4%]). A total of 728 participants (39.7%) had illness that lasted 28 days or longer (28-89 days: 364 [19.9%]; ≥90 days: 364 [19.9%]). Participants who were unvaccinated prior to infection (risk...