Mechanobiological modulation of blood–brain barrier permeability by laser stimulation of endothelial-targeted nanoparticles

作者：Xiaoqing Li, Qi Cai, Blake A. Wilson, Hanwen Fan, Harsh Dave, Monica Giannotta, Robert Bachoo, Zhenpeng Qin · 发表于：Nanoscale · 年份：2023 · DOI：10.1039/d2nr05062e · 被引用次数：26 · 研究领域：Photoacoustic and Ultrasonic Imaging、Connexins and lens biology、Laser-Ablation Synthesis of Nanoparticles

influx with contributions from mechanosensitive ion channels (TRPV4, Piezo1). We provide insight into how the excitation of tight junction protein (JAM-A)-targeted and endothelial (glycocalyx)-targeted AuNPs leads to similar mechanobiological modulation of BBB permeability while targeting the glycocalyx significantly improves the nanoparticle accumulation in the brain. The results will be critical for guiding the future development of this technology for brain disease treatment.