The Oligodendrocyte Lineage during Myelination and Remyelination

作者：Monique Dubois‐Dalcq, Regina C. Armstrong · 年份：2023 · DOI：10.1201/9780203746141-4 · 被引用次数：12 · 研究领域：Neurogenesis and neuroplasticity mechanisms、Neuroinflammation and Neurodegeneration Mechanisms、MicroRNA in disease regulation

Direct evidence of extensive migration of oligodendrocyte lineage cells also comes from experiments with central nervous system (CNS) grafts from normal neonatal mice into shiverer mutant mice, which are unable to synthesize myelin basic protein (MBP) because of a deletion in the MBP gene. Extensive remyelination appears to require the generation of oligodendrocytes during demyelination. Discerning mitogenic signals which can affect the oligodendrocyte-type 2 astrocyte (O-2A) lineage in the adult CNS is now an important task. Accordingly, AA platelet-derived growth factor dimers proved to be more potent mitogens for O-2A progenitors of newborn rat optic nerve than BB dimmers. There is recent evidence that platelet-derived growth factor which is highly expressed in the CNS in vivo is an essential mitogen that triggers growth and timely differentiation of O-2A progenitor cells. Recent studies have revealed that most glial cells exhibit membrane channels which are selectively permeable to specific ions. Such is the case for O-2A lineage cells.