O -GalNAc glycosylation affects the immunogenicity of the receptor-binding domain (RBD) of SARS-CoV-2 spike protein

作者：Yongheng Rong, Xingyun Wang, Weian Mao, Min Chen, Shengjun Wang, Peng George Wang, Yunjiao He, Yun Kong · 发表于：Chemical Communications · 年份：2023 · DOI：10.1039/d2cc06583e · 被引用次数：8 · 研究领域：SARS-CoV-2 and COVID-19 Research、Immunotherapy and Immune Responses、vaccines and immunoinformatics approaches

glycosylation reactions. The inhibition ability against hACE2 binding of antibodies induced with Tn-RBD was 30-40% increased compared to that induced with RBD. This result implies that Tn-glycosylation might play important roles in the immunogenicity of the RBD protein, which should be considered in the design of novel vaccines to fight against COVID-19.