Development of a General and Selective Nanostructured Cobalt Catalyst for the Hydrogenation of Benzofurans, Indoles and Benzothiophenes

作者：Bei Zhou, Vishwas G. Chandrashekhar, Zhuang Ma, Carsten Kreyenschulte, Stephan Bartling, Henrik Lund, Matthias Beller, Rajenahally V. Jagadeesh · 发表于：Angewandte Chemie International Edition · 年份：2023 · DOI：10.1002/anie.202215699 · 被引用次数：26 · 研究领域：Asymmetric Hydrogenation and Catalysis、Nanomaterials for catalytic reactions、Catalysis for Biomass Conversion

The selective hydrogenation of benzofurans in the presence of a heterogeneous non-noble metal catalyst is reported. The developed optimal catalytic material consists of cobalt-cobalt oxide core-shell nanoparticles supported on silica, which has been prepared by the immobilization and pyrolysis of cobalt-DABCO-citric acid complex on silica under argon at 800 °C. This novel catalyst allows for the selective hydrogenation of simple and functionalized benzofurans to 2,3-dihydrobenzofurans as well as related heterocycles. The versatility of the reported protocol is showcased by the reduction of selected drugs and deuteration of heterocycles. Further, the stability, recycling, and reusability of the Co-nanocatalyst are demonstrated.