Recent advances of tanshinone in regulating autophagy for medicinal research

作者：Sha Wu, Kui Zhao, Jie Wang, Nannan Liu, Kaidi Nie, Luming Qi, Lina Xia · 发表于：Frontiers in Pharmacology · 年份：2023 · DOI：10.3389/fphar.2022.1059360 · 被引用次数：29 · 研究领域：Autophagy in Disease and Therapy、Ginseng Biological Effects and Applications、Traditional Chinese Medicine Analysis

, tanshinone has recently shown profound effects in alleviating and treating various diseases by regulating autophagy. However, compared to the remarkable achievements in the known pharmacological effects of this traditional Chinese medicine, there is a lack of a concise and comprehensive review deciphering the mechanism by which tanshinone regulates autophagy for medicinal research. In this context, we concisely review the advances of tanshinone in regulating autophagy for medicinal research, including human cancer, the nervous system, and cardiovascular diseases. The pharmacological effects of tanshinone targeting autophagy involve the regulation of autophagy-related proteins, such as Beclin-1, LC3-II, P62, ULK1, Bax, ATG3, ATG5, ATG7, ATG9, and ATG12; the regulation of the PI3K/Akt/mTOR, MEK/ERK/mTOR, Beclin-1-related, and AMPK-related signaling pathways; the accumulation of reactive oxygen species (ROS); and the activation of AMPK. Notably, we found that tanshinone played a dual role in human cancers in an autophagic manner, which may provide a new avenue for potential clinical application. In brief, these findings on autophagic tanshinone and its derivatives provide a new clue for expediting medicinal research related to tanshinone compounds and autophagy.