A science-based agenda for health-protective chemical assessments and decisions: overview and consensus statement

作者：Tracey J. Woodruff, Swati D. G. Rayasam, Daniel A. Axelrad, Patricia D. Koman, Nicholas Chartres, Deborah H. Bennett, Linda S. Birnbaum, Phil Brown, Courtney C. Carignan, Courtney Cooper, Carl F. Cranor, Miriam L. Diamond, Shari Franjevic, Eve C. Gartner, Dale B. Hattis, Russ B. Hauser, Wendy Heiger‐Bernays, Rashmi Joglekar, Juleen Lam, Jonathan I. Levy, Patrick M. MacRoy, Maricel V. Maffini, Emily Marquez, Rachel A. Morello-Frosch, Keeve E. Nachman, Greylin H. Nielsen, Catherine Oksas, Dimitri Abrahamsson, Heather B. Patisaul, Sharyle Patton, Joshua F. Robinson, Kathryn M. Rodgers, Mark S. Rossi, Ruthann A. Rudel, Jennifer Beth Sass, Sheela Sathyanarayana, Ted H. Schettler, Rachel M. Shaffer, Bhavna Shamasunder, Peggy Shepard, Kristin Shrader‐Frechette, Gina M Solomon, Wilma A. Subra, Laura N. Vandenberg, Julia Varshavsky, Roberta F. White, Ken Zarker, Lauren A. Zeise · 发表于：Environmental Health · 年份：2023 · DOI：10.1186/s12940-022-00930-3 · 被引用次数：52 · 研究领域：Environmental Justice and Health Disparities、Effects and risks of endocrine disrupting chemicals、Chemical Safety and Risk Management

The manufacture and production of industrial chemicals continues to increase, with hundreds of thousands of chemicals and chemical mixtures used worldwide, leading to widespread population exposures and resultant health impacts. Low-wealth communities and communities of color often bear disproportionate burdens of exposure and impact; all compounded by regulatory delays to the detriment of public health. Multiple authoritative bodies and scientific consensus groups have called for actions to prevent harmful exposures via improved policy approaches. We worked across multiple disciplines to develop consensus recommendations for health-protective, scientific approaches to reduce harmful chemical exposures, which can be applied to current US policies governing industrial chemicals and environmental pollutants. This consensus identifies five principles and scientific recommendations for improving how agencies like the US Environmental Protection Agency (EPA) approach and conduct hazard and risk assessment and risk management analyses: (1) the financial burden of data generation for any given chemical on (or to be introduced to) the market should be on the chemical producers that benefit from their production and use; (2) lack of data does not equate to lack of hazard, exposure, or risk; (3) populations at greater risk, including those that are more susceptible or more highly exposed, must be better identified and protected to account for their real-world risks; (4) hazard and risk...