A Positively Selected fur -R88H Mutation Enhances Helicobacter pylori Fitness in a High-Salt Environment and Alters Fur-Dependent Regulation of Gene Expression

作者：John T. Loh, Emily Struttmann, Natalie R. Favret, M. Lorena Harvey, Suman Pakala, Abha Chopra, Mark S. McClain, Timothy L. Cover · 发表于：Infection and Immunity · 年份：2023 · DOI：10.1128/iai.00420-22 · 被引用次数：8 · 研究领域：Helicobacter pylori-related gastroenterology studies、Galectins and Cancer Biology

Both Helicobacter pylori infection and a high-salt diet are risk factors for gastric cancer. We previously showed that a mutation in fur (encoding the ferric uptake regulator variant Fur-R88H) was positively selected in H. pylori strains isolated from experimentally infected Mongolian gerbils receiving a high-salt diet.