Osteopontin and Cancer: Insights into Its Role in Drug Resistance

作者：Chengcheng Hao, Jane Lane, Wen G. Jiang · 发表于：Biomedicines · 年份：2023 · DOI：10.3390/biomedicines11010197 · 被引用次数：35 · 研究领域：Bone and Dental Protein Studies、Cancer-related Molecular Pathways、Cancer, Hypoxia, and Metabolism

Cancer is one of the leading causes of mortality worldwide. Currently, drug resistance is the main obstacle in cancer treatments with the underlying mechanisms of drug resistance yet to be fully understood. Osteopontin (OPN) is a member of the integrin binding glycophosphoprotein family that is overexpressed in several tumour types. It is involved in drug transport, apoptosis, stemness, energy metabolism, and autophagy, which may contribute to drug resistance. Thus, understanding the role of OPN in cancer drug resistance could be important. This review describes the OPN-based mechanisms that might contribute to cancer drug resistance, demonstrating that OPN may be a viable target for cancer therapy to reduce drug resistance in sensitive tumours.