Advancing the science on chemical classes

作者：Maricel V. Maffini, Swati D. G. Rayasam, Daniel A. Axelrad, Linda S. Birnbaum, Courtney Cooper, Shari Franjevic, Patrick M. MacRoy, Keeve E. Nachman, Heather B. Patisaul, Kathryn M. Rodgers, Mark Rossi, Ted Schettler, Gina Solomon, Tracey J. Woodruff · 发表于：Environmental Health · 年份：2023 · DOI：10.1186/s12940-022-00919-y · 被引用次数：25 · 研究领域：Effects and risks of endocrine disrupting chemicals、Chemistry and Chemical Engineering、Contact Dermatitis and Allergies

BACKGROUND: Hazard identification, risk assessment, regulatory, and policy activity are usually conducted on a chemical-by-chemical basis. Grouping chemicals into categories or classes is an underutilized approach that could make risk assessment and management of chemicals more efficient for regulators. OBJECTIVE AND METHODS: While there are some available methods and regulatory frameworks that include the grouping of chemicals (e.g.,same molecular mechanism or similar chemical structure) there has not been a comprehensive evaluation of these different approaches nor a recommended course of action to better consider chemical classes in decision-making. This manuscript: 1) reviews current national and international approaches to grouping; 2) describes how groups could be defined based on the decision context (e.g., hazard/risk assessment, restrictions, prioritization, product development) and scientific considerations (e.g., intrinsic physical-chemical properties); 3) discusses advantages of developing a decision tree approach for grouping; 4) uses ortho-phthalates as a case study to identify and organize frameworks that could be used across agencies; and 5) discusses opportunities to advance the class concept within various regulatory decision-making scenarios. RESULTS: Structural similarity was the most common grouping approach for risk assessment among regulatory agencies (national and state level) and non-regulatory organizations, albeit with some variations in its definit...