A low-carbon high inulin diet improves intestinal mucosal barrier function and immunity against infectious diseases in goats

作者：Chunmei Yuan, Shuiping Wang, Kefyalew Gebeyew, Xin Yang, Shaoxun Tang, Chuanshe Zhou, Nazir Ahmad Khan, Zhiliang Tan, Yong Liu · 发表于：Frontiers in Veterinary Science · 年份：2023 · DOI：10.3389/fvets.2022.1098651 · 被引用次数：17 · 研究领域：Ruminant Nutrition and Digestive Physiology、Animal health and immunology、Microbial Metabolites in Food Biotechnology

Introduction Abrupt weaning is a major stressful event, contributing to intestinal abnormalities and immune system dysfunction in weaned kids. Inulin is a prebiotic fiber with many positive functions, including promoting intestinal fermentation and enhancing host immunity in monogastric animals. However, the effects of a high-inulin, energy-rich diet on ruminal fermentation characteristics, methane emission, growth performance, and immune systems of weaned kids have not been investigated. Methods A fully automated in vitro fermentation system was used to investigate ruminal fermentation characteristics and methane emission of a mixed substrate of inulin and fat powder (1.31: 1) in comparison with maize grain-based starter concentrate. During a 1-week adaptation and 4-week trial phase, 18 weaned kids (8.97 ± 0.19 kg) were randomly assigned to two groups, one with a conventional diet (83% maize grain; CON) and the other with a low-carbon, high-inulin diet (41.5% maize grain, 14.4% fat powder, 18.9% inulin; INU). Results In the in vitro rumen fermentation experiment, the total gas production was not different ( p > 0.05); however, a lower ( p < 0.05) methane production was observed for INU as compared to CON. The average daily gain and the ratio of feed intake and growth performance of kids fed with INU were higher ( p < 0.05) than those fed with CON. Serum concentrations of alanine transaminase (ALT) and lactate dehydrogenase (LDH) were lower ( p < 0...