Altered intestinal microbiota composition with epilepsy and concomitant diarrhea and potential indicator biomarkers in infants

作者：Tingting Liu, Fengan Jia, Ying Guo, Qi Wang, Xiaoge Zhang, Fan Chang, Yun Xie · 发表于：Frontiers in Microbiology · 年份：2023 · DOI：10.3389/fmicb.2022.1081591 · 被引用次数：16 · 研究领域：Gut microbiota and health、Gastrointestinal motility and disorders、Probiotics and Fermented Foods

Introduction The diversity and dysregulation of intestinal microbiota is related to the pathology of epilepsy. Gut microbiota plays an important role in epilepsy, and regulating intestinal microbiota through exogenous intervention can alleviate symptoms. However, there are no studies about the effects of epilepsy-related diarrhea on gut microbiota. Methods The diversity and dysregulation of intestinal microbiota is related to the pathology of epilepsy. Gut microbiota plays an important role in epilepsy, and regulating intestinal microbiota through exogenous intervention can alleviate symptoms. However, there are no studies about the effects of epilepsy-related diarrhea on gut microbiota. To evaluate changes in gut microbiota structure and composition in patients with epilepsy and associated diarrhea, the structure and composition of the fecal microbiota among patients with epilepsy (EP, 13 cases), epilepsy with diarrhea (ED, 13 cases), and probiotic treatments (PT, 13 cases), and healthy controls (CK, seven cases) were investigated and validated by utilizing high-throughput 16S rRNA sequencing. Results The results showed that the α-diversity indexes indicated that richness and phylogenetic diversity had no significant differences among groups. However, the variation of β-diversity indicated that the structure and composition of intestinal microbiota were significantly different among the CK, EP, ED, and PT groups (permutational multivariate analysis of variance, p -value = 0....