Reversible pH-responsive MRI contrast with paramagnetic polymer micelles

作者：Connor M. Ellis, Daohe Yuan, Ferenc Emil Mózes, Jack J. J. J. Miller, Jason J. Davis · 发表于：Chemical Communications · 年份：2023 · 被引用次数：12 · 研究领域：Lanthanide and Transition Metal Complexes、Advanced MRI Techniques and Applications、MRI in cancer diagnosis

Paramagnetically-doped polymer micelles, containing an ionizable poly(acrylic acid) (PAA) block, support high-contrast MR imaging at clinically relevant field strengths in a manner that is strongly pH responsive. A reversible switch in polymer strand charge specifically has a direct impact on local rigidity, and rotational correlation time characteristics, of the integrated Gd-chelate, driving a ∼50% amplitude switch in positive contrast.