Research progress on circular RNA vaccines

作者：Yu Bai, Dong Liu, Qian He, Jianyang Liu, Qunying Mao, Zhenglun Liang · 发表于：Frontiers in Immunology · 年份：2023 · DOI：10.3389/fimmu.2022.1091797 · 被引用次数：55 · 研究领域：Circular RNAs in diseases、MicroRNA in disease regulation、RNA Interference and Gene Delivery

Owing to the success of linear mRNA coronavirus disease 2019 (COVID-19) vaccines, biopharmaceutical companies and research teams worldwide have attempted to develop more stable circular RNA (circRNA) vaccines and have achieved some preliminary results. This review aims to summarize key findings and important progress made in circRNA research, the in vivo metabolism and biological functions of circRNAs, and research progress and production process of circRNA vaccines. Further, considerations regarding the quality control of circRNA vaccines are highlighted herein, and the main challenges and problem-solving strategies in circRNA vaccine development and quality control are outlined to provide a reference for circRNA vaccine-related research.