The Importance of Fatty Acid Precision Nutrition: Effects of Dietary Fatty Acid Composition on Growth, Hepatic Metabolite, and Intestinal Microbiota in Marine Teleost Trachinotus ovatus

作者：Guanrong Zhang, Lijun Ning, Kunsheng Jiang, Jun Zheng, Junfeng Guan, Hengji Li, Yongcai Ma, Kun Wu, Chao Xu, Dizhi Xie, Fang Chen, Shuqi Wang, Yuanyou Li · 发表于：Aquaculture Nutrition · 年份：2023 · DOI：10.1155/2023/2556799 · 被引用次数：16 · 研究领域：Aquaculture Nutrition and Growth、Aquaculture disease management and microbiota、Animal Nutrition and Physiology

Our recent study demonstrated that diet with blend oil (named BO1) as lipid, which is designed on the base of essential fatty acid requirement of Trachinotus ovatus, achieved good performance. Here, to confirm its effect and investigate the mechanism, three isonitrogenous (45%) and isolipidic (13%) diets (D1-D3) only differing in dietary lipids, which were, respectively, fish oil (FO), BO1, and blend oil 2 (BO2) consisting of FO and soybean oil at 2 : 3, were formulated and used to feed the T. ovatus juveniles (average initial weight: 7.65 g) for 9 weeks. The results showed that the weight gain rate of fish fed D2 was higher than that of fish fed D3 ( P < 0.05 ) and had no significant difference from that of fish fed D1 ( P > 0.05 ). Correspondingly, compared with the D3 group, fish of the D2 group exhibited better oxidative stress parameters such as lower serum malondialdehyde content and inflammatory indexes in the liver such as the lower expression level of genes encoding four interleukin proteins and tumor necrosis factor α, as well as higher hepatic immune-related metabolites such as valine, gamma-aminobutyric acid, pyrrole-2-carboxylic acid, tyramine, l-targinine, p-synephrine, and butyric acid ( P < 0.05 ). Furthermore, the intestinal probiotic (Bacillus) proportion was significantly higher, while the pathogenic bacteria (Mycoplasma) proportion was significantly lower in the D2 group than that in the D3 group ( P < 0.05 ...