Toxicity Study of a New Scale Inhibitor for Seawater Desalination

作者：Lian Duan, Yimin Li, Wen Gu, Chao Wang, Ying Shi, Hongbin Yang, Mengmeng Wang, Yuehan Long, Song Tang, Jian Kong, Shaoping Zhang, Lixia Zhang, Lei Wei, Chong Wang, Kai Lu · 发表于：Research Square · 年份：2023 · DOI：10.21203/rs.3.rs-2439011/v1 · 研究领域：Calcium Carbonate Crystallization and Inhibition、Environmental Toxicology and Ecotoxicology

Abstract Maleic acid polymer scale inhibitor is a new domestic seawater desalination scale inhibitor. Guided by the Organization for Economic Cooperation and Development method, this study tested the acute oral toxicity, sub-chronic toxicity and genotoxicity of this new inhibitor. The LD 50 obtained from the acute oral toxicity test was 6810 and 9260 mg/kg·BW for male and female rats, as well as 1/5, 1/10 and 1/20 LD 50 were as the dose for sub-chronic toxicity test. It showed the weight of male rats with high dose was significantly lower than the control group during the exposure period ( p <0.05), and the food consumption in the first 4 weeks was lower than the control group ( p _week1 = 0.0261, p _week4 = 0.00222). The blood biochemical results showed the UREA in the medium- and high-dose groups were significantly higher than the control group ( p _ female medium = 0.0047, p _high = 0.0037; p _male medium = 0.0026, p _ high <0.001), and increased as a dose dependence. Based on UREA results, the NOAEL and LOAEL were 1/20 LD 50 and 1/10 LD 50 , respectively (males: 340.5 and 170.25 mg/kg·BW, females: 436 and 231.5 mg/kg·BW). Comet assay in vitro and Mammalian Erythrocyte Micronucleus Test were jointly to judge genotoxicity. This inhibitor did not cause chromosome aberrations in mouse bone marrow cells. However, the tail moment of CHO cell in all groups ( p <0.01) and the DNA% in tail in the 1/4 IC 50 and IC 50 groups were higher than the negative control ( p <0.0...