Lactate, histone lactylation and cancer hallmarks

作者：Xinyu Lv, Yingying Lv, Xiaofeng Dai · 发表于：Expert Reviews in Molecular Medicine · 年份：2023 · DOI：10.1017/erm.2022.42 · 被引用次数：218 · 研究领域：Epigenetics and DNA Methylation、Cancer, Hypoxia, and Metabolism、Metabolism, Diabetes, and Cancer

Histone lactylation, an indicator of lactate level and glycolysis, has intrinsic connections with cell metabolism that represents a novel epigenetic code affecting the fate of cells including carcinogenesis. Through delineating the relationship between histone lactylation and cancer hallmarks, we propose histone lactylation as a novel epigenetic code priming cells toward the malignant state, and advocate the importance of identifying novel therapeutic strategies or dual-targeting modalities against lactylation toward effective cancer control. This review underpins important yet less-studied area in histone lactylation, and sheds insights on its clinical impact as well as possible therapeutic tools targeting lactylation.