Protective Efficiency Comparison of Direct and Remote Ischemic Preconditioning on Ischemia Reperfusion Injury of the Liver in Patients Undergoing Partial Hepatectomy

作者：Erliang Kong, Chang Yuan, Yongchang Li, Tian Tian, Yan He, Xudong Feng · 发表于：BioMed Research International · 年份：2023 · DOI：10.1155/2023/2763320 · 被引用次数：13 · 研究领域：Organ Transplantation Techniques and Outcomes、Cardiac Ischemia and Reperfusion、Hydrogen's biological and therapeutic effects

Objective . Ischemia reperfusion injury greatly damages liver function and deteriorates the prognosis of patients undergoing partial hepatectomy. This study is to compare the protective efficiency of direct and remote ischemic preconditioning (DIPC and RIPC) on ischemia reperfusion injury of the liver in patients undergoing partial hepatectomy. Methods . 90 patients scheduled for partial hepatectomy were enrolled and randomly divided into control ( n = 30), DIPC ( n = 30), and RIPC ( n = 30) groups. Baseline and surgery characteristics were collected, and ischemic preconditioning methods were carried out. Intraoperative hemodynamics, liver function and liver reserve capacity, oxidative stress, and inflammatory responses were measured, and the incidence of postoperative adverse reactions was calculated finally. Results . 10 patients were excluded from the study, and finally, the eligible patients in three groups were 27, 28, and 25, separately. No significant differences were observed in baseline and surgery characteristics among the three groups. SBP and DBP were significantly higher after hepatic portal vein occlusion while they were significantly lower after surgery in the DIPC and RIPC groups compared with that in the control group, SBP and DBP were of great fluctuation at different time points in the control group while they showed much more stabilization in the DIPC and RIPC groups. ALT, AST, and TBIL were significantly decreased on days 1, 3, and 5 after surgery, and IC...