Preoperative prediction of early recurrence of HBV-related hepatocellular carcinoma (≤5 cm) by visceral adipose tissue index

作者：Zongqian Wu, Jie Cheng, Xi-xi Xiao, Hua-rong Zhang, Jian Wang, Juan Peng, Chen Liu, Ping Cai, Xiaoming Li · 发表于：Frontiers in Surgery · 年份：2023 · DOI：10.3389/fsurg.2022.985168 · 被引用次数：7 · 研究领域：Liver Disease Diagnosis and Treatment、Hepatocellular Carcinoma Treatment and Prognosis、Cancer, Lipids, and Metabolism

Background This study aimed to investigate whether visceral adipose tissue index (VATI) is a significant risk factor for the early recurrence (ER) of HBV-related hepatocellular carcinoma (HCC) (≤5 cm) after hepatectomy. Methods The recruited cohort patients who were positive for hepatitis B virus, presented with surgically confirmed HCC (≤5 cm) from Army Medical University (internal training cohort: n = 192) and Chongqing Medical University (external validation group: n = 46). We measured VATI, subcutaneous adipose tissue index (SATI) via computed tomography (CT). ER was defined as recurrence within 2 years after hepatectomy. The impact of parameters on outcome after hepatectomy for HCC was analyzed. Results Univariate analysis showed that alpha-fetoprotein levels ( p = 0.044), body mass index (BMI) ( p < 0.001), SATI ( p < 0.001), and VATI ( p < 0.001) were significantly different between ER and non-ER groups in internal training cohort. Multivariate analysis identified VATI as an independent risk factor for ER (odds ratio = 1.07, 95% confidence interval: 1.047–1.094, p < 0.001), with a AUC of 0.802, based on the cut-off value of VATI, which was divided into high risk (≥37.45 cm 2 /m 2 ) and low risk (<37.45 cm 2 /m 2 ) groups. The prognosis of low risk group was significantly higher than that of high risk group ( p < 0.001). The AUC value of VATI in external validation group was 0.854. Conclusion VATI was an independent risk factor ...