Establishment of a gut-on-a-chip device with controllable oxygen gradients to study the contribution of Bifidobacterium bifidum to inflammatory bowel disease

作者：Jun Liu, Ronghao Lu, Xiaolin Zheng, Wensheng Hou, Xiaoying Wu, Hezhao Zhao, Guixue Wang, Tian Tian · 发表于：Biomaterials Science · 年份：2023 · DOI：10.1039/d2bm01490d · 被引用次数：45 · 研究领域：3D Printing in Biomedical Research、Innovative Microfluidic and Catalytic Techniques Innovation、Microfluidic and Bio-sensing Technologies

Numerical simulations were applied to guide the design of a gut-on-a-chip device with controllable oxygen gradients. Bifidobacterium bifidum was demonstrated to increase the stability of the intestinal epithelial barrier on the disease model.