A mesothelium divides the subarachnoid space into functional compartments

作者：Kjeld Møllgård, Felix R. M. Beinlich, Peter Kusk, Leo M. Miyakoshi, Christine Delle, Virginia Plá, Natalie Hauglund, Tina Esmail, Martin Kaag Rasmussen, Ryszard S. Gomolka, Yuki Mori, Maiken Nedergaard · 发表于：Science · 年份：2023 · DOI：10.1126/science.adc8810 · 被引用次数：269 · 研究领域：Cerebrospinal fluid and hydrocephalus、Traumatic Brain Injury and Neurovascular Disturbances、Intracranial Aneurysms: Treatment and Complications

The central nervous system is lined by meninges, classically known as dura, arachnoid, and pia mater. We show the existence of a fourth meningeal layer that compartmentalizes the subarachnoid space in the mouse and human brain, designated the subarachnoid lymphatic-like membrane (SLYM). SLYM is morpho- and immunophenotypically similar to the mesothelial membrane lining of peripheral organs and body cavities, and it encases blood vessels and harbors immune cells. Functionally, the close apposition of SLYM with the endothelial lining of the meningeal venous sinus permits direct exchange of small solutes between cerebrospinal fluid and venous blood, thus representing the mouse equivalent of the arachnoid granulations. The functional characterization of SLYM provides fundamental insights into brain immune barriers and fluid transport.