The Role of Total White Blood Cell Count in Antipsychotic Treatment forPatients with Schizophrenia

作者：Yamin Zhang, Shiwan Tao, Jeremy Coid, Wei Wei, Qiang Wang, Weihua Yue, Hao Yan, Liwen Tan, Qi Chen, Guigang Yang, Tianlan Lu, Lifang Wang, Fuquan Zhang, Jianli Yang, Keqing Li, Luxian Lv, Qingrong Tan, Hongyan Zhang, Xin Ma, Fude Yang, Lingjiang Li, Chuanyue Wang, Liansheng Zhao, Wei Deng, Wanjun Guo, Xiaohong Ma, Dai Zhang, Tao Li · 发表于：Current Neuropharmacology · 年份：2023 · DOI：10.2174/1570159x21666230104090046 · 被引用次数：16 · 研究领域：Tryptophan and brain disorders、Schizophrenia research and treatment、Inflammatory Biomarkers in Disease Prognosis

Background: Total white blood cell count (TWBCc), an index of chronic and low-grade inflammation, is associated with clinical symptoms and metabolic alterations in patients with schizophrenia. The effect of antipsychotics on TWBCc, predictive values of TWBCc for drug response, and role of metabolic alterations require further study. Methods: Patients with schizophrenia were randomized to monotherapy with risperidone, olanzapine, quetiapine, aripiprazole, ziprasidone, perphenazine or haloperidol in a 6-week pharmacological trial. We repeatedly measured clinical symptoms, TWBCc, and metabolic measures (body mass index, blood pressure, waist circumference, fasting blood lipids and glucose). We used mixed-effect linear regression models to test whether TWBCc can predict drug response. Mediation analysis to investigate metabolic alteration effects on drug response. Results: At baseline, TWBCc was higher among patients previously medicated. After treatment with risperidone, olanzapine, quetiapine, perphenazine, and haloperidol, TWBCc decreased significantly (p < 0.05). Lower baseline TWBCc predicted greater reductions in Positive and Negative Syndrome Scale (PANSS) total and negative scores over time (p < 0.05). We found significant mediation of TWBCc for effects of waist circumference, fasting low-density lipoprotein cholesterol, and glucose on reductions in PANSS total scores and PANSS negative subscale scores (p < 0.05). Conclusion: TWBCc is affected by certain antipsyc...