Dual-stimuli responsive smart nanoprobe for precise diagnosis and synergistic multi-modalities therapy of superficial squamous cell carcinoma

作者：Peisen Zhang, Yingying Cui, Jian Wang, Junwei Cheng, Lichong Zhu, Chuang Liu, Saisai Yue, Runxin Pang, Jiaoqiong Guan, Bixia Xie, Ni Zhang, Meng Qin, Lihong Jing, Yi Hou, Yue Lan · 发表于：Journal of Nanobiotechnology · 年份：2023 · DOI：10.1186/s12951-022-01759-1 · 被引用次数：29 · 研究领域：Nanoplatforms for cancer theranostics、Cancer Research and Treatments、Graphene and Nanomaterials Applications

Abstract Background Although the promising advancements of current therapeutic approaches is available for the squamous cell carcinoma (SCC) patients, the clinical treatment of SCC still faces many difficulties. The surgical irreparable disfigurement and the postoperative wound infection largely hamper the recovery, and the chemo/radiotherapy leads to toxic side effects. Results Herein, a novel pH/Hyaluronidase (HAase) dual-stimuli triggered smart nanoprobe Fe III TA@HA has been designed through the biomineralization of Fe 3+ and polyphenol tannic acid (TA) under the control of hyaluronic acid (HA) matrix. With the HA residues on the outer surface, Fe III TA@HA nanoprobes can specifically target the SCC cells through the over-expressed CD44, and accumulate in the carcinoma region after intravenously administration. The abundant HAase in carcinoma microenvironment will trigger the degradation of HA molecules, thereby exposing the Fe III TA complex. After ingesting by tumor cells via CD44 mediated endocytosis, the acidic lysosomal condition will further trigger the protonation of TA molecules, finally leading to the Fe 3+ release of nanoprobe, and inducing a hybrid ferroptosis/apoptosis of tumor cells through peroxidase activity and glutathione depletion. In addition, Owing to the outstanding T 1 magnetic resonance imaging (MRI) performance and phototermal conversion efficiency of nanoprobes, the MRI-guided photothermal therapy (PTT) can be also combined to complement the Fe 3+...