Kinetic Controlled Chirality Transfer and Induction in 2D Hydrogen‐Bonding Assemblies of Glycylglycine on Au(111)

作者：Xin Zhang, Haoxuan Ding, Yang Shu, Hualin Yang, Xiaoqing Yang, Bosheng Li, Xueting Xing, Yaojie Sun, Guangxin Gu, Xiaorui Chen, Jianzhi Gao, Minghu Pan, Lifeng Chi, Quanmin Guo · 发表于：Small · 年份：2023 · DOI：10.1002/smll.202207111 · 被引用次数：11 · 研究领域：Supramolecular Self-Assembly in Materials、Surface Chemistry and Catalysis、Crystallography and molecular interactions

Chirality transfer is of vital importance that dominates the structure and functionality of biological systems and living matters. External physical stimulations, e.g. polarized light and mechanical forces, can trigger the chirality symmetry breaking, leading to the appearance of the enantiomeric entities created from a chiral self-assembly of achiral molecule. Here, several 2D assemblies with different chirality, synthesized on Au(111) surface by using achiral building blocks - glycylglycine (digly), the simplest polypeptide are reported. By delicately tuning the kinetic factors, i.e., one-step slow/rapid deposition, or stepwise slow deposition with mild annealing, achiral square hydrogen-bond organic frameworks (HOF), homochiral rhombic HOF and racemic rectangular assembly are achieved, respectively. Chirality induction and related symmetry broken in assemblies are introduced by the handedness (H-bond configurations in principle) of the assembled motifs and then amplified to the entire assemblies via the interaction between motifs. The results show that the chirality transfer and induction of biological assemblies can be tuned by altering the kinetic factors instead of applying external forces, which may offer an in-depth understanding and practical approach to peptide chiral assembly on the surfaces and can further facilitate the design of desired complex biomolecular superstructures.