The role of receptor‐type protein tyrosine phosphatases in cancer

作者：Zhengyuan Lv, Tianming Wang, Xin Cao, Mengting Sun, Yuan Qu · 发表于：Precision Medical Sciences · 年份：2023 · DOI：10.1002/prm2.12090 · 被引用次数：17 · 研究领域：Protein Tyrosine Phosphatases、Galectins and Cancer Biology、RNA modifications and cancer

Abstract Receptor‐type protein tyrosine phosphatases (RPTPs), Class I protein tyrosine phosphatases, are involved in human tumor cell proliferation, apoptosis, migration, and invasion through reversible phosphorylation of tyrosine residues. This review summarizes the expression and role of RPTPs in cancer and illustrates the signaling pathway mechanisms of effecting oncogenesis, tumor progression, prognosis, and angiogenesis, so as to provide more effective targets for gene therapy of related cancers.